wejdan AL-shakarchi; Noora Thamer Abdulaziz; Yasser Fakri Mustafa
Volume 4, Issue 7 , July 2022, , Pages 645-656
Abstract
Flavonoids, plant-derived phytochemicals, which are abundantly found in various fruits and vegetables, are potent antioxidants because of their ability to trap damaging free radicals. ...
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Flavonoids, plant-derived phytochemicals, which are abundantly found in various fruits and vegetables, are potent antioxidants because of their ability to trap damaging free radicals. Among this phytochemical family, quercetin, which belongs to the flavonols subfamily, has garnered a lot of attention. Flavonoids, plant-derived phytochemicals which are abundantly found in various fruits and vegetables, are potent antioxidants because of their ability to trap damaging free radicals. Among this phytochemical family, quercetin, which belongs to the flavonols subfamily, has garnered a lot of attention. The trapping capacity of quercetin is thought to safeguard against a variety of aging-related diseases. The extent and mode of intestinal quercetin absorption have been identified recently. The glycosidic form of quercetin is hydrolyzed, affording the quercetin, which is subsequently transformed into one of its numerous metabolites. Recognizing the mechanism of quercetin as an antioxidant necessitates the synthesis and analysis of quercetin metabolites. This review examines the literature on flavonoids overall as well as quercetin in particular. To underline the relevance of flavonoids, their chemical backbones and antioxidant capabilities are described. However, because the degree of intestinal absorption of flavonoids is debatable, their antioxidant capacity may be an irrelevant matter. Many of the pharmacokinetic studies have indicated that superior absorbed antioxidants involving ascorbic acid are responsible for the antioxidant potential observed upon ingesting particular foods such as green apples. This review highlights the chemistry, pharmacokinetic, and pharmacological effects of flavonoids in general as well as quercetin and its metabolites in particular, by surveying the corresponding in vitro and in vivo studies.
